SH514
Product Specifications
Target
Others, IFNAR
Related Pathways
Others, Immunology/Inflammation
Bioactivity
SH514 is a specific IRF4 inhibitor with an IC50 of 2.63 μM, binding to the DNA-binding domain (IRF4-DBD) of IRF4 to block its transcriptional activity and inhibit the expression of downstream genes such as CCNC, CANX, E2F5, CMYC, HK2, and Blimp1, and inhibits the expression of MM cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC, making it useful for studying multiple myeloma and malignant haematological diseases.
Smiles
C[C@@H]([C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C(=O)C=C4[C@@]3(C=C(C(=O)C4(C)C)C#N)C)C)C(=O)NC5=CC=C(C=C5)OC
Molecular Formula
C32H38N2O4
Molecular Weight
514.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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