AS-254s
Product Specifications
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay) . It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.
Smiles
C1COCCC1N2C=C(C3=C2C(=C(C=C3)CNC(=O)C4CC5(C4)CCN(CC5)CCNC(=O)C6=NC=CS6)Cl)C7=CC(=CC=C7)C(=S)N
Molecular Formula
C36H41ClN6O3S2
Molecular Weight
705.332
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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