HAChE-IN-10
Product Specifications
CAS Number
3058182-98-9
Target
Cholinesterase (ChE), Beta Amyloid
Related Pathways
Neuroscience
Bioactivity
HAChE-IN-10 (Compound ET11) is an inhibitor of human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. This compound is capable of scavenging free radicals and exhibits antioxidant activity. Additionally, hAChE-IN-10 demonstrates metal-chelating properties, inhibiting Cu2+-induced Aβ1-42 aggregation, reducing amyloid plaque formation, and offering neuroprotective effects. It also ameliorates cognitive impairment in mice induced by Scopolamine.
Smiles
O=C(NCCCNC=1C=2C=CC(Cl)=CC2N=C3C1CCCC3)C4=NN(C(O)=C4)C5=NC=C(F)C=C5
Molecular Formula
C25H24ClFN6O2
Molecular Weight
494.948
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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