KRAS G12C inhibitor 69
Product Specifications
Target
Ras|||ERK|||Kras
Related Pathways
GPCR/G Protein|||MAPK
Bioactivity
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.
Smiles
C=CC(=O)N1CCN(CC1)C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F)OC[C@@]56CCCN5C[C@@H](C6)F
Molecular Formula
C29H29ClF3N5O3
Molecular Weight
588.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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