Avitinib maleate dihydrate
Product Specifications
CAS Number
1822357-78-7
Target
EGFR|||Apoptosis|||BTK
Related Pathways
Apoptosis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
Avitinib (Abivertinib) maleate dihydrate is a third-generation, irreversible, orally active selective EGFR inhibitor with IC50 values of 0.18 nM for EGFRL858R and EGFRT790M, and 7.68 nM for wild-type EGFR. Additionally, Avitinib maleate dihydrate functions as a BTK inhibitor, promoting apoptosis in mantle cell lymphoma cells and inhibiting BTK phosphorylation, demonstrating anticancer properties.
Smiles
OC(/C=C\C(O)=O)=O.FC1=C(N2CCN(CC2)C)C=CC(NC3=NC(OC4=CC(NC(C=C)=O)=CC=C4)=C5C(NC=C5)=N3)=C1.O.O
Molecular Formula
C30H34FN7O8
Molecular Weight
639.631
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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