CDK4/6/HDAC-IN-1
Product Specifications
Target
CDK, HDAC, Apoptosis
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.
Smiles
CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CC(=O)NC5=CC=C(C=C5)/C=C/C(=O)NO)C6CCCC6)C(=O)C
Molecular Formula
C35H39N9O5
Molecular Weight
665.742
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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