MASP-2-IN-1
Product Specifications
Target
Serine Protease, Potassium Channel
Related Pathways
Membrane transporter/Ion channel, Proteases/Proteasome
Bioactivity
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 μM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 μM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.
Smiles
C1=CC=C(C=C1)S(=O)(=O)NC2=CN=C(N=C2)CC(=O)NCC3=CC=C(C=C3)C4=CN=C(N4)N
Molecular Formula
C22H21N7O3S
Molecular Weight
463.512
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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