PROTAC PARP1 degrader-4
Product Specifications
Target
PARP, PROTACs
Related Pathways
DNA Damage/DNA Repair, PROTAC, Chromatin/Epigenetic
Bioactivity
PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCC(=O)N(C)CC4=CC=C(C=C4)C5=C6CCNC(=O)C7=C6C(=CC(=C7)F)N5)O
Molecular Formula
C51H62FN7O6S
Molecular Weight
920.145
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL514855V 500 µL Each
Uchl1 Mouse shRNA Lentiviral Particle (Locus ID 22223)
Sign In for Pricing
View Details 
bsm-61486R-Cy7-01 20 µL
Lipoprotein lipase Recombinant Antibody, Cy7 Conjugated
Sign In for Pricing
View Details bsm-61486R-Cy7-02 100 µL
Lipoprotein lipase Recombinant Antibody, Cy7 Conjugated
Sign In for Pricing
View Details 248662-FITC 100 µL
MEF2B (Myocyte Enhancer Factor 2B, FLJ32599, FLJ46391, MGC189732, MGC189763, RSRFR2) (FITC) discontinued
Sign In for Pricing
View Details