PROTAC PARP1 degrader-4
Product Specifications
Target
PARP|||PROTACs
Related Pathways
DNA Damage/DNA Repair|||PROTAC|||Chromatin/Epigenetic
Bioactivity
PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCC(=O)N(C)CC4=CC=C(C=C4)C5=C6CCNC(=O)C7=C6C(=CC(=C7)F)N5)O
Molecular Formula
C51H62FN7O6S
Molecular Weight
920.145
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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