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WIZ degrader 8

Product Specifications

CAS Number

2879251-26-8

Target

Histone Acetyltransferase

Related Pathways

Chromatin/Epigenetic

Bioactivity

WIZ degrader 8 (compound 10) is a potent and selective molecular glue degrader of the transcription factor WIZ, effectively inducing HbF expression. It promotes WIZ degradation and HbF induction, suggesting its potential use as an inhibitor for sickle cell disease.

Smiles

O=C1N(CC=2C1=CC=C(O[C@H]3CN(CC)C[C@H](C)C3)C2)C4C(=O)NC(=O)CC4

Molecular Formula

C21H27N3O4

Molecular Weight

385.457

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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