EGFR-IN-139
Product Specifications
CAS Number
1574321-31-5
Target
EGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Bioactivity
EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S) . It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC) .
Smiles
Cl.O=C(C=1OC2=C(N=CC(=C2C1)CN3CC=4C=CC=CC4CC3)C)C5=CC=C6OCCOC6=C5
Molecular Formula
C27H25ClN2O4
Molecular Weight
476.951
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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