ER covalent antagonist-1
Product Specifications
CAS Number
2757498-74-9
Target
Estrogen Receptor/ERR, Apoptosis
Related Pathways
Apoptosis, Endocrinology/Hormones
Bioactivity
ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα) . This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.
Smiles
O(C1=C(C(=O)C2=CC=CC=C2)SC=3C1=CC=C(O)C3)C4=CC=C(OC5CN(C/C=C/C(=O)N6CCCCC6)C5)C=C4
Molecular Formula
C33H32N2O5S
Molecular Weight
568.683
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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