HPK1-IN-56
Product Specifications
CAS Number
2901054-39-3
Target
Interleukin, MAPK
Related Pathways
Immunology/Inflammation, MAPK
Bioactivity
HPK1-IN-56 (Compound A29) is an HPK1 inhibitor with an IC50 of 2.70 nM. It inhibits downstream p-SLP76 in Jurkat T cells with an IC50 of 8.1 nM. Additionally, HPK1-IN-56 induces IL-2 production in human PBMCs. This compound exhibits anticancer properties, enhancing T cell cytotoxicity and the antitumor efficacy of anti-PD-1 antibodies.
Smiles
N1=NC=2C(N=C1NC=3C=C4C(=CC3OC)CCN(C)C4)=CC(=CC2N)C=5C=NC=C(N)C5C
Molecular Formula
C24H26N8O
Molecular Weight
442.516
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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