HLB-0532259
Product Specifications
CAS Number
2566733-45-5
Target
PROTACs, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, PROTAC, Cell Cycle/Checkpoint
Bioactivity
HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)
Smiles
O=C(NCCCCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4)NC=5N=CC=6C=C(C(=O)N(C)C)N(C6N5)C7CCCC7
Molecular Formula
C40H44N8O7
Molecular Weight
748.827
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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