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CA IX/VEGFR-2-IN-3

Product Specifications

Target

VEGFR, Carbonic Anhydrase

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, Metabolism

Bioactivity

CAIX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. It exhibits anticancer activity by inhibiting the growth of MCF-7 breast cancer cells (IC50 of 22.33 μM) and mouse fibroblast cell line 3T3, where cell viability is reduced to below 40% at a concentration of 100 μM. This compound is applicable for research in the field of cancer treatment.

Smiles

CC1=C(C=C(C=C1)NC(=O)CN2C(=O)/C(=C/C3=CC=C(C=C3)Cl)/SC2=O)S(=O)(=O)N

Molecular Formula

C19H16ClN3O5S2

Molecular Weight

465.93

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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