CA IX/VEGFR-2-IN-3
Product Specifications
Target
VEGFR, Carbonic Anhydrase
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Metabolism
Bioactivity
CAIX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. It exhibits anticancer activity by inhibiting the growth of MCF-7 breast cancer cells (IC50 of 22.33 μM) and mouse fibroblast cell line 3T3, where cell viability is reduced to below 40% at a concentration of 100 μM. This compound is applicable for research in the field of cancer treatment.
Smiles
CC1=C(C=C(C=C1)NC(=O)CN2C(=O)/C(=C/C3=CC=C(C=C3)Cl)/SC2=O)S(=O)(=O)N
Molecular Formula
C19H16ClN3O5S2
Molecular Weight
465.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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