JNK3 inhibitor-9
Product Specifications
Target
Beta Amyloid|||JNK|||GSK-3
Related Pathways
Neuroscience|||Stem Cells|||PI3K/Akt/mTOR signaling|||MAPK
Bioactivity
JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3?/?, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from A?1-42 toxicity.
Smiles
C1C[C@H](CN(C1)C(=O)C2CC2)NC3=NC=CC(=N3)N4C=C(C(=N4)C(=O)N)/C=C/C5=CC=CC=C5
Molecular Formula
C25H27N7O2
Molecular Weight
457.528
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1183601-01 0.02 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Ascorbate-specific phosphotransferase enzyme IIB component (ulaB)
Ask
View Details 
MBS1183601-02 0.1 mg (E-Coli)
Recombinant Escherichia coli O157:H7 Ascorbate-specific phosphotransferase enzyme IIB component (ulaB)
Ask
View Details 
MBS1183601-03 0.02 mg (Yeast)
Recombinant Escherichia coli O157:H7 Ascorbate-specific phosphotransferase enzyme IIB component (ulaB)
Ask
View Details MBS1183601-04 0.1 mg (Yeast)
Recombinant Escherichia coli O157:H7 Ascorbate-specific phosphotransferase enzyme IIB component (ulaB)
Ask
View Details