Tamoxifen-PEG-Clozapine
Product Specifications
Target
Estrogen Receptor/ERR, PROTACs
Related Pathways
Endocrinology/Hormones, PROTAC
Bioactivity
Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader. It targets ERα for degradation through the ubiquitin-proteasome system by utilizing the E3 ubiquitin ligase component N-recognin 5. This compound is applicable in cancer research. (Pink: ERα inhibitor; Black: linker; Blue: CRBN Ligand)
Smiles
CC/C(=C(/C1=CC=C(C=C1)O)\C2=CC=C(C=C2)OCCN(C)C(=O)CCC(=O)NCCOCCOCCOCCN3CCN(CC3)C4=NC5=C(C=CC(=C5)Cl)NC6=CC=CC=C64)/C7=CC=CC=C7
Molecular Formula
C54H63ClN6O7
Molecular Weight
943.567
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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