IHAC
Product Specifications
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
IHAC is an inhibitor-HSP90 anchoring chimera that covalently binds to the BRD4 ligand (+) -JQ-1, targeting HSP90 and thereby inhibiting cancer cell proliferation. This compound also triggers an anti-tumor immune response and is effective in suppressing the recurrence and metastasis of 4T1 breast cancer in mouse models.
Smiles
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCC4=CN(N=N4)CCCC(=O)N(CC#N)S(=O)(=O)C5=CC=C(C=C5)C(=O)NCCCN6C7=NC=NC(=C7N=C6SC8=C(C=C9C(=C8)OCO9)I)N)C1=CC=C(C=C1)Cl)C
Molecular Formula
C50H46ClIN16O7S3
Molecular Weight
1241.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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