TRK-IN-30
Product Specifications
Target
Apoptosis, ERK, PI3K, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, MAPK, PI3K/Akt/mTOR signaling
Bioactivity
TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.
Smiles
COC1=C(C=C(C=C1)NC(=O)C2=C(C(=CC=C2)NC3=CC4=C(C=C3)C(=CN4)C#N)N)OC
Molecular Formula
C24H21N5O3
Molecular Weight
427.455
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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