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CDKL5/GSK3-IN-1

Product Specifications

CAS Number

844442-32-6

Target

GSK-3

Related Pathways

PI3K/Akt/mTOR signaling, Stem Cells

Bioactivity

CDKL5/GSK3-IN-1 (Compound 2) acts as a potent and selective chemical probe for CDKL5 and GSK3. It effectively inhibits CDKL5 and GSK3α/β with IC50 values of 4.6 nM for CDKL5, 24 nM for GSK3β, and 9.5 nM for GSK3α in NanoBRET assays. This compound is useful in the study of central nervous system disorders.

Smiles

O=C(NC1=CNN=C1C(=O)NC2CCNCC2)C=3C=C(F)C=C(F)C3

Molecular Formula

C16H17F2N5O2

Molecular Weight

349.335

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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