CDKL5/GSK3-IN-1
Product Specifications
CAS Number
844442-32-6
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells
Bioactivity
CDKL5/GSK3-IN-1 (Compound 2) acts as a potent and selective chemical probe for CDKL5 and GSK3. It effectively inhibits CDKL5 and GSK3?/? with IC50 values of 4.6 nM for CDKL5, 24 nM for GSK3?, and 9.5 nM for GSK3? in NanoBRET assays. This compound is useful in the study of central nervous system disorders.
Smiles
O=C(NC1=CNN=C1C(=O)NC2CCNCC2)C=3C=C(F)C=C(F)C3
Molecular Formula
C16H17F2N5O2
Molecular Weight
349.335
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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