JAK05
Product Specifications
Target
Antibacterial|||TNF|||Prostaglandin Receptor|||ATPase|||COX
Related Pathways
Immunology/Inflammation|||Microbiology/Virology|||Apoptosis|||Neuroscience|||GPCR/G Protein|||Membrane transporter/Ion channel
Bioactivity
JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-?, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.
Smiles
CC(=O)OC[C@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)N2C(=S)N(C(=N2)C3=CC=NC=C3)C4=CC=C(C=C4)Cl)OC(=O)C)OC(=O)C)OC(=O)C
Molecular Formula
C27H27ClN4O9S
Molecular Weight
619.043
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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