ALK/ROS1-IN-5
Product Specifications
Target
Apoptosis, ROS Kinase, ALK
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.
Smiles
COC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)N6CCOCC6
Molecular Formula
C32H28F2N4O3
Molecular Weight
554.586
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP314155 20 µg
CCBL2 (KYAT3) (NM_001008661) Human Recombinant Protein
Sign In for Pricing
View Details 
TP309584M 100 µg
PRMT10 (PRMT9) (NM_138364) Human Recombinant Protein
Sign In for Pricing
View Details