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ALK/ROS1-IN-5

Product Specifications

Target

Apoptosis, ROS Kinase, ALK

Related Pathways

Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.

Smiles

COC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)N6CCOCC6

Molecular Formula

C32H28F2N4O3

Molecular Weight

554.586

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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