Tubulin polymerization-IN-72
Product Specifications
Target
Apoptosis, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Apoptosis
Bioactivity
Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis) . The IC50 for its activity against cancer cells is 0.4-2.7 nM.
Smiles
CNC1=NC2=C(C=C(C=C2)F)C(=N1)N3CCCC4=C3C=CC(=C4)OC
Molecular Formula
C19H19FN4O
Molecular Weight
338.379
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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