Keap1-IN-1
Product Specifications
Target
Nrf2, Reductase
Related Pathways
Metabolism, Immunology/Inflammation, Endocrinology/Hormones
Bioactivity
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.
Smiles
CCP1(=O)CCN(CC1)C2=C(N=C(S2)S(=O)(=O)CC)S(=O)(=O)C3=C(C(=CC=C3)Cl)Cl
Molecular Formula
C17H21Cl2N2O5PS3
Molecular Weight
531.434
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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