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SR2640

Product Specifications

CAS Number

105350-26-3

Target

Leukotriene Receptor

Related Pathways

GPCR/G Protein

Bioactivity

SR2640 is a potent and highly selective LTD4/LTE4 antagonist, specifically inhibiting LTD4-induced contractions in guinea pig ileum and tracheal smooth muscle in a concentration-dependent manner, without affecting histamine-induced contractions. It blocks the binding of 0.4 nM [3H]LTD4 to guinea pig lung membrane receptors with an IC50 of 23 nM. SR2640 also causes a parallel rightward shift in the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs when administered intravenously, with the degree of shift correlating positively with its dosage. SR2640 is applicable for asthma research.

Smiles

O=C(O)C=1C=CC=CC1NC=2C=CC=C(OCC3=NC=4C=CC=CC4C=C3)C2

Molecular Formula

C23H18N2O3

Molecular Weight

370.401

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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