CDK4/6-IN-23
Product Specifications
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.
Smiles
CC(=O)N1CCC2(CC1)CC(=O)C3=C(O2)C=C(C=C3)C4=NC(=NC=C4F)NC5=NC=C(C=C5)N6CCN(CC6)C(=O)C7CC7
Molecular Formula
C32H34FN7O4
Molecular Weight
599.655
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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