ChREBPα/14-3-3 regulator-1
Product Specifications
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the interaction between carbohydrate response element-binding protein (ChREBP) and 14-3-3 proteins, with an EC50 of 3.8 μM. It effectively safeguards β cells from glucolipotoxicity, preserving cell function and making it relevant for type 2 diabetes research.
Smiles
C1=CC=C(C(=C1)OCC(=O)NCC(C2=CC(=CC=C2)F)(F)F)P(=O)(O)O
Molecular Formula
C16H15F3NO5P
Molecular Weight
389.263
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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