GSK-3β inhibitor 24
Product Specifications
Target
GSK-3, Microtubule Associated, Wnt/beta-catenin
Related Pathways
Stem Cells, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.
Smiles
C1OC2=C(O1)C=C(C=C2)C3=C(C=NC=C3)NC(=O)C4=CNC5=C4C=C(C=N5)C6=CC=CC=C6
Molecular Formula
C26H18N4O3
Molecular Weight
434.446
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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