MLK3-IN-1
Product Specifications
Target
FAK, MLK
Related Pathways
Cytoskeletal Signaling, Angiogenesis, MAPK, Tyrosine Kinase/Adaptors
Bioactivity
MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.
Smiles
CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3)C(F)(F)F
Molecular Formula
C20H16F6N4O2S
Molecular Weight
490.422
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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