SEH inhibitor-19
Product Specifications
Target
Interleukin, Epoxide Hydrolase, TNF
Related Pathways
Metabolism, Immunology/Inflammation, Apoptosis
Bioactivity
SEH inhibitor-19 (Compound (R) -14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.
Smiles
COC1=C(C=C2[C@H]3CC4=C(CN3CCC2=C1)C=C(C=C4)NC(=O)NCC5=CC=C(C=C5)OC(F)(F)F)OC
Molecular Formula
C28H28F3N3O4
Molecular Weight
527.535
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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