VEGFR-2-IN-58
Product Specifications
Target
Apoptosis|||VEGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis
Bioactivity
VEGFR-2-IN-58 (Compound 7b) is a VEGFR-2 inhibitor with an IC50 of 42.5 nM. It shows selective cytotoxicity against cancer cells, induces cell cycle arrest at the G2/M phase, and triggers apoptosis by increasing BAX expression and decreasing Bcl2 expression. Additionally, VEGFR-2-IN-58 hampers cancer cell wound closure.
Smiles
C1=CC=C(C=C1)C2=C(OC(=C2C#N)/N=C/NC3=CC=C(C=C3)Cl)C4=CC=CC=C4
Molecular Formula
C24H16ClN3O
Molecular Weight
397.856
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6385111-01 0.1 mL
MCM2 (DNA Replication Licensing Factor MCM2, Minichromosome Maintenance Protein 2 Homolog, Nuclear Protein BM28, BM28, CCNL1, CDCL1, KIAA0030, MGC10606) (MaxLight 550)
Ask
View Details MBS6385111-02 5x 0.1 mL
MCM2 (DNA Replication Licensing Factor MCM2, Minichromosome Maintenance Protein 2 Homolog, Nuclear Protein BM28, BM28, CCNL1, CDCL1, KIAA0030, MGC10606) (MaxLight 550)
Ask
View Details 
