DNA ligase-IN-2
Product Specifications
CAS Number
635681-64-0
Target
DNA/RNA Synthesis, Antibacterial
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Microbiology/Virology
Bioactivity
DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.
Smiles
O=C(N)C1=CC=2C(=O)C3=CC(F)=CC=C3OC2N=C1N
Molecular Formula
C13H8FN3O3
Molecular Weight
273.219
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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