HSN748
Product Specifications
CAS Number
2409925-53-5
Target
MNK, c-RET, FLT, PDGFR, Bcr-Abl
Related Pathways
MAPK, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Bioactivity
HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.
Smiles
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=NC=C(C#CC4=CN=C5C=CC=NN45)C3
Molecular Formula
C27H24F3N7O
Molecular Weight
519.521
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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