P53 Activator 14
Product Specifications
CAS Number
2922588-44-9
Target
Apoptosis, MDM-2/p53
Related Pathways
Apoptosis
Bioactivity
P53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.
Smiles
O=C(NC1=CC=C(OCC2=NC=CC=C2)C(Cl)=C1)C3=CC=C(C=C3)CN4CCN(C(=O)C5CC5)CC4
Molecular Formula
C28H29ClN4O3
Molecular Weight
505.008
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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