Org 274179-0
Product Specifications
CAS Number
1421683-12-6
Target
TSH Receptor
Related Pathways
GPCR/G Protein
Bioactivity
Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI) -mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD) .
Smiles
C[C@@]1(C=2C(N(C(C)=O)CC1)=CC=C(NC(CCC3=CC(C(F)(F)F)=CC=C3)=O)C2)C4=CC=CC=C4
Molecular Formula
C28H27F3N2O2
Molecular Weight
480.521
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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