Mutant IDH1-IN-3
Product Specifications
CAS Number
1648909-73-2
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolism
Bioactivity
Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.
Smiles
OC=1C(=CC(=CC1CN2C=NC=C2)C(C)(C)CC(C)(C)C)CN3C=NC=C3
Molecular Formula
C22H30N4O
Molecular Weight
366.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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