PROTAC AR Degrader-9
Product Specifications
Target
PROTACs, Androgen Receptor
Related Pathways
PROTAC, Endocrinology/Hormones
Bioactivity
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]
Smiles
C1CC(CN(C1)C2=CC=C(C=C2)C(=O)NC3CCC(=O)NC3=O)CN4CCC(CC4)C5=CC=C(C=C5)C(=O)NC6CCC(CC6)OC7=CC(=C(C=C7)C#N)Cl
Molecular Formula
C43H49ClN6O5
Molecular Weight
765.339
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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