JAK-IN-39
Product Specifications
CAS Number
2250013-34-2
Target
JAK, TNF
Related Pathways
Chromatin/Epigenetic, Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Stem Cells
Bioactivity
JAK-IN-39 (compound 11) is a JAK inhibitor with IC50 values of 0.05 nM for JAK1, 1.18 nM for JAK2, and 0.03 nM for JAK3. It reduces cell viability in TF-1 cells and inhibits the production of TNFα and INFγ in lymphocytes in vitro.
Smiles
N(C=1N2C(=CC(=N2)C=3N=C(OC)C=CC3)N=CC1C(N)=O)[C@H]4C(C)(C)CN(CC4)C5=CC=C(C#N)N=N5
Molecular Formula
C25H26N10O2
Molecular Weight
498.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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