Ferroptosis-IN-17
Product Specifications
Target
Glutathione Peroxidase|||Ferroptosis
Related Pathways
Metabolism|||Apoptosis
Bioactivity
Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 ?M. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) . In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.
Smiles
CCNC(=O)C1=CC(=C(C=C1)NC2CCCCC2)NS(=O)(=O)C3=CC=C(C=C3)[N+](=O)[O-]
Molecular Formula
C21H26N4O5S
Molecular Weight
446.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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