TMX-2138
Product Specifications
CAS Number
2488892-07-3
Target
PROTACs, CDK
Related Pathways
Cell Cycle/Checkpoint, PROTAC
Bioactivity
TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.
Smiles
O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)S(=O)(=O)NCCOCCOCCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6
Molecular Formula
C40H43BrFN9O11S
Molecular Weight
956.791
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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