FLT3-IN-29
Product Specifications
Target
ROS, Reactive Oxygen Species, FLT, Apoptosis
Related Pathways
Apoptosis, Metabolism, Angiogenesis, Immunology/Inflammation, NF-κB, Tyrosine Kinase/Adaptors
Bioactivity
FLT3-IN-29 (Compound MY-10) is an FLT3 inhibitor with IC50 values of 6.5 nM and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants, respectively. It induces cell cycle arrest at the G0/G1 phase and effectively triggers apoptosis (Apoptosis) . Additionally, FLT3-IN-29 reduces reactive oxygen species (ROS) and mitochondrial membrane potential (MMP), displaying anti-leukemic properties.
Smiles
CC(C)N1CCC(CC1)NC2=NC=C(C(=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)C(=O)N
Molecular Formula
C25H30N6O2
Molecular Weight
446.545
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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