Mal-VC-PAB-DMEA-PNU-159682

Product Specifications

CAS Number

1178887-17-6

Target

Drug-Linker Conjugates for ADC|||Topoisomerase

Related Pathways

DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related

Bioactivity

Mal-VC-PAB-DMEA-PNU-159682 is an agent-linker conjugate for ADCs, designed by linking the topoisomerase II inhibitor PNU-159682 with the lysosomally cleavable dipeptide Mc-VC-PAB, demonstrating potent antitumor activity. Additionally, Mal-VC-PAB-DMEA-PNU-159682 can be utilized for the synthesis of Anti-CD22-NMS249.

Smiles

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