Mal-VC-PAB-DMEA-PNU-159682
Product Specifications
CAS Number
1178887-17-6
Target
Drug-Linker Conjugates for ADC|||Topoisomerase
Related Pathways
DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related
Bioactivity
Mal-VC-PAB-DMEA-PNU-159682 is an agent-linker conjugate for ADCs, designed by linking the topoisomerase II inhibitor PNU-159682 with the lysosomally cleavable dipeptide Mc-VC-PAB, demonstrating potent antitumor activity. Additionally, Mal-VC-PAB-DMEA-PNU-159682 can be utilized for the synthesis of Anti-CD22-NMS249.
Smiles
O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCN(C(OCC5=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN6C(=O)C=CC6=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C5)=O)C)C)=O)=O)(O)C1)[C@H]7C[C@@]8(N9[C@](O[C@@]8([C@H](C)O7)[H])([C@@H](OC)OCC9)[H])[H]
Molecular Formula
C66H83N9O22
Molecular Weight
1354.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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