PROTAC HDAC6 degrader 3
Product Specifications
Target
PROTACs, HDAC
Related Pathways
PROTAC, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCC(=O)NCC4=CC=CC(=C4)CNC5=NC=C(C=N5)C6=NN=C(O6)C(F)F)O
Molecular Formula
C46H56F2N10O9S
Molecular Weight
963.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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