PROTAC SMARCA2/4 degrader-36

PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.

CC1(C)C=2N(C=3C1=CC(=CC3)C4CCN(C[C@H]5CC[C@@H](CC5)C6=CN([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)C)N=N6)CC4)C=%10C(C(=O)N2)=C(Cl)C=CC%10