Purinostat
Product Specifications
CAS Number
1929583-17-4
Target
HDAC
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.
Smiles
O=C(NO)C1=CN=C(N=C1)N(C)CC2=NC=3C(=NC(=NC3N4CCOCC4)C=5C=CC(N)=CC5)N2C
Molecular Formula
C23H26N10O3
Molecular Weight
490.518
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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