BG11
Product Specifications
CAS Number
3065877-52-0
Target
Ferroptosis, Apoptosis
Related Pathways
Apoptosis
Bioactivity
BG11 promotes the accumulation of Fe2+ and intracellular lipid peroxides, leading to ferroptosis (iron-dependent cell death) . It regulates the expression of Bax and Bcl-2 proteins, inducing apoptosis (programmed cell death) in MDA-MB-231 cells. BG11 also causes cell cycle arrest at the G0/G1 and S phases, inhibiting the proliferation of TNBC cancer cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. Additionally, it reduces cell migration and invasion and demonstrates antitumor effects in mouse models.
Smiles
CC=1C2=C(N3C([C@H](CC(NC4CCN(C(CCl)=O)CC4)=O)N=C2C5=CC=C(Cl)C=C5)=NN=C3C)SC1C
Molecular Formula
C26H28Cl2N6O2S
Molecular Weight
559.511
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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